A thiol probe for measuring unfolded protein load and proteostasis in cells
收藏NIAID Data Ecosystem2026-03-10 收录
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资源简介：
When proteostasis becomes unbalanced, unfolded proteins accumulate and can aggregate. However, probes quantifying proteostasis imbalance are lacking. We report a dye, tetraphenylethene maleimide (TPE-MI) that can measure unfolded protein load.TPE-MI fluorescence is enhanced upon reaction with cellular proteomes under conditions promoting accumulation of unfolded proteins and, via proteomic analysis, can track which proteins expose more cysteine residues under stress.
创建时间：
2018-10-24
