Mycobacterium tuberculosis Genome sequencing. Mycobacterium tuberculosis

Among antitubercular drugs, p-aminosalicylic acid (PAS) was one of the earliest antitubercular drug identified, yet the mechanism of resistance and genetic determinants remain poorly understood. In this study we conducted a systematic analysis of spontaneous PAS resistant isolates of M. tuberculosis. This sample is one of seven PAS resistant samples found to harbor mutations in the sahH gene