Selection of the optimal weight matrix by core genes and evaluation by the genome-wide association (GWA) p-values.

Note:aφ and η denote threshold proportion in the core gene set and the candidate gene set.bSelection criteria: position j≤160, position l≤1200 and mean≥900. Definition of j and l is shown in footnote d and e below. The weight matrices with mean marked in bold.cWeight matrix is ordered by ωassociation, ωlinkage, ωexpression_human, ωliterature_human, ωkegg, ωexpression_rat, ωliterature_animal.dPosition j represents the position of the φ-th core gene locates in the η-th top ranked candidate genes.ePosition l represents the position of the last core gene locates in the ranked candidate genes.fMean: total number of random subsets having significant different p-value distribution from the top ranked candidate genes (Wilcoxon rank-sum test, p