Data Extraction Table.

BackgroundAbdominal aortic aneurysm (AAA) has a high mortality rate after rupture. This study systematically explored the risk factors associated with AAA in the general population using a meta-analytic approach.Materials and methodsWe conducted a systematic search of PubMed, Embase, and Cochrane Library databases to identify relevant literature. The search was conducted through May 2025. Factors considered in more than three studies were included in the analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were used as effect estimates and all pooled analyses were performed using a random-effects model.ResultsThirty-four studies reporting 34,551 AAA cases were selected for meta-analysis. Increased risk of AAA was associated with male (OR: 3.78; 95% CI: 2.80–5.10; P P P P P P P P P = 0.001) and family history of AAA (OR: 2.26; 95% CI: 1.58–3.25; P P = 0.007). Furthermore, the risk of AAA was not affected by advanced age, alcohol intake, cancer, being overweight, or physical activity. The association between AAA risk and sex, smoking, hypertension, diabetes mellitus, renal disease, and a family history of AAA differs between Eastern and Western countries.ConclusionsWe systematically explored the risk factors for AAA. AAA represent a significant public health concern. Thus, early intervention and health education targeting these risk factors are necessary to prevent their occurrence. Registration: INPLASY2023120024