An impedance-based chemiresistor for the real-time detection of gut microbiota-generated short-chain fatty acids

Short-chain fatty acids (SCFAs) are key molecules produced by gut bacteria in the intestine, that are absorbed into the bloodstream and strongly influence human health. SCFA disruption and imbalances have been linked to many diseases; however, they are seldom used diagnostically as their detection requires extensive sample preparation and expensive equipment. In this work, an electrochemical sensor was developed to enable real-time, quantitative measurement of SCFAs from complex samples in the liquid phase without the need for extraction, evaporation, or destruction.短链脂肪酸（short-chain fatty acids, SCFAs）是肠道菌群在肠道内生成的关键代谢分子，可被吸收入血液循环系统，并对人体健康产生显著影响。短链脂肪酸水平紊乱与失衡与多种疾病密切相关；然而由于其检测需要复杂的样品前处理流程以及昂贵的仪器设备，这类标志物极少被应用于临床诊断。本研究开发了一种电化学传感器，可无需萃取、蒸发或样品破坏处理步骤，直接对复杂液相样品中的短链脂肪酸实现实时定量检测。