Crystal structure of Protein Kinase A in complex with the PKI peptide and a pyridinylbenzamide based inhibitor

Crystal structure of Protein Kinase A in complex with the PKI peptide and a pyridinylbenzamide based inhibitor Descriptor: N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide, PKI peptide, cAMP-dependent protein kinase catalytic subunit alpha Authors: Judge, R.A, Hobson, A.D. Deposit date: 2018-08-01 Release date: 2018-11-14 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design. J. Med. Chem., 61, 2018

结合有PKI肽与吡啶基苯甲酰胺类抑制剂的蛋白激酶A（Protein Kinase A）晶体结构。描述符：N-[(2,3-二氢-1,4-苯并二噁英-5-基)甲基]-4-(吡啶-4-基)苯甲酰胺、PKI肽、cAMP依赖性蛋白激酶催化亚基α；作者：Judge, R.A.、Hobson, A.D.；提交日期：2018-08-01；发布日期：2018-11-14；末次修改日期：2024-11-13；实验方法：X射线衍射（2.8 Å）；引用文献：《基于结构药物设计筛选选择性双靶点ROCK1与ROCK2抑制剂》，《药物化学杂志（J. Med. Chem.）》，第61卷，2018年。