DEEP CHARACTERIZATION OF PAIRED CHROMATIN AND TRANSCRIPTOMES IN FOUR IMMUNE CELL TYPES FROM MULTIPLE SCLEROSIS PATIENTS

Supplementary Figure 1: Overview of the data
analysis pipeline

Supplementary
Figure 2: Volcano plots showing
differentially expressed (DE) genes between HC and RR in CD4, CD8, CD14, and
CD19. DE analysis was performed on all genes using linear models that, in
addition to disease status, included age as a covariate (Methods). DE genes
(FDR=0.2) have been highlighted with blue if upregulated in RR and red if
downregulated in RR.

SUPPLEMENTARY TABLES:

Supplementary
table 1: ATAC Seq differentially bound regions in all 4 cell
types

Supplementary
table 2: Transcription factor enrichment

Supplementary
table 3: RNA Seq differentially expressed genes

Supplementary
table 4: Correlation of differentially expressed and
differentially bound regions