The crystal structure of anti-apoptotic Mcl-1 protein in complex with 2, 5-substituted benzoic acid inhibitor 21

The crystal structure of anti-apoptotic Mcl-1 protein in complex with 2, 5-substituted benzoic acid inhibitor 21 Descriptor: 2-[({4-[(4-tert-butylphenyl)methyl]piperazin-1-yl}sulfonyl)amino]-5-[(2-phenylethyl)sulfanyl]benzoic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 Authors: Yang, Y, Stuckey, J.A, Nikolovska-Coleska, Z. Deposit date: 2019-08-29 Release date: 2020-03-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins. J.Med.Chem., 63, 2020

与2,5-取代苯甲酸类抑制剂21结合的抗凋亡髓系细胞白血病蛋白Mcl-1（anti-apoptotic Mcl-1 protein）的晶体结构。描述符：2-[({4-[(4-叔丁基苯基)甲基]哌嗪-1-基}磺酰基)氨基]-5-[(2-苯乙基)硫基]苯甲酸，诱导型髓系细胞分化蛋白Mcl-1（Induced myeloid leukemia cell differentiation protein Mcl-1）。作者：Yang, Y.、Stuckey, J.A.、Nikolovska-Coleska, Z.。提交日期：2019-08-29，发布日期：2020-03-04，最后修改日期：2023-10-11。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.9 Å。引用文献：《2,5-取代苯甲酸类双靶点抗凋亡Mcl-1与Bfl-1蛋白抑制剂的发现与表征》，发表于J.Med.Chem.，2020年，第63卷。