Liver toxicity induced by rhubarb extract in normal rats with regard to survival and biochemical indices.

N, normal rat group without treatment; ND1-ND4, normal rat groups treated with rhubarb extract at dosages of 2.00, 5.40, 14.69 and 40.00 g kg−1, respectively.ALT, serum alanine aminotransferase; AST, serum aspartate aminotransferase; AP, alkaline phosphatase; TBIL, total bile acids; TP, total protein; GLO, globulin; HA, hyaluronic acid; LN, laminin; TGF-β1, transforming growth factor β1.a The initial number of animals in each group of the study was 18.△ P compared to the N group.