Association of the most statistically significant SNPs with the rate of change in FEV1 (mL/year) in the meta-analysis of the five cohort studies with ≥3 FEV1 measurements per participant (n = 10,476).

Definition of abbreviations: Chr = chromosome; SE = standard error; SNP = single-nucleotide polymorphism.*Data reported are the meta-analysis results of the SNP-by-time interaction term from the GWAS mixed effects model. A positive β-coefficient indicates an attenuation of FEV1 decline and a negative β-coefficient an acceleration of FEV1 decline.