Nonsense SNPs and prediction of NMD.

aThis prediction is based on that mRNA would be destroyed if a stop codon occurs in the 5�� side of the boundary, which is 50�C55 nucleotides upstream from the 3�� end of the second to last exon. Here, the nonsense SNPs located in the 5�� side of the boundary, which was set at 50 nucleotides upstream from the 3�� end of the second to last exon, were predicted to cause NMD.bThis number includes SNPs in genes consisting of only one exon.cP = 0.0033 by Fisher's exact test.