Data from: Molecular genetics of sex identification, breed ancestry and polydactyly in the Norwegian Lundehund breed

The Norwegian Lundehund breed of dog has undergone a severe loss of genetic diversity as a result of inbreeding and epizootics of canine distemper. As a consequence, the breed is extremely homogeneous and accurate sex identification is not always possible by standard screening of X-chromosomal loci. To improve our genetic understanding of the breed we genotyped 17 individuals using a genome-wide array of 170 000 single nucleotide polymorphisms (SNPs). Standard analyses based on expected homozygosity of X-chromosomal loci failed in assigning individuals to the correct sex, as determined initially by physical examination and confirmed with the Y-chromosomal marker, amelogenin. This demonstrates that identification of sex using standard SNP assays can be erroneous in highly inbred individuals.挪威伦德猎犬（Norwegian Lundehund）这一犬种因近交以及犬瘟热兽疫流行，发生了严重的遗传多样性丧失。由此导致该品种犬的遗传背景极为同质化，仅依托X染色体位点的标准筛查，无法始终完成精准的性别鉴定。为加深对该犬种的遗传学认知，研究团队使用包含17万个单核苷酸多态性（single nucleotide polymorphisms, SNPs）的全基因组芯片，对17个个体进行了基因分型。基于X染色体位点预期纯合性的标准分析，无法将个体准确分配至对应性别——这一性别最初通过体格检查确定，并通过Y染色体标记基因釉原蛋白（amelogenin）得以验证。该结果表明，在高度近交的个体中，采用标准SNP检测进行性别鉴定可能出现误差。