Spatial and non-spatial memory in the Morris water maze in IL-1R1^−/− and WT mice.

(a) The latency to reach the hidden platform, and (b) the path length were assessed in IL-1R1−/− mice (n = 11) and WT mice (n = 20) in the spatial memory water maze task across 9 trials with 1 hour inter trial interval. (c) Probe trials performed after 9 trials and 27 trials (dotted line shows 25%), and (d) non-spatial memory (flag trial) in IL-1R1−/− mice and WT. Data are expressed as mean±SEM and were analysed by two-way repeated-measures ANOVA with strain as between subjects factor and time as within subjects factor (a, b) or by t-test (c, d). * denotes main effect of strain (p = 0.02).