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Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia

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NIAID Data Ecosystem2026-05-01 收录
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Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine. Refer to individual Series

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2024-04-24
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