PureBeta

We present PureBeta, a statistical framework that uses genome-wide DNA methylation data as the only input to first estimate tumor purity of samples and then adjust DNA methylation values of individual CpGs with respect to tumor purity to better reflect somatic changes in tumor cells and improve biological inference. Any updates to the R package can be found on https://github.com/StaafLab/PureBeta. Here we have added a copy of the R package (v1.1.0) and reference data for calculating tumor purity and adjusting Illumina 450K DNA methylation beta values of breast or lung cancer (adenocarcinoma and squamous cell carcinoma).