Peptidyl-tRNA hydrolase 2 is an essential negative regulator of peripartum cardiomyopathy

We conducted transcriptomic profiling of PPCM patient and normal hearts to examine differential gene expression and identified the peptidyl-tRNA hydrolase 2 (PTRH2, Bit-1; BIT1) gene and protein were significantly downregulated in PPCM patient hearts. Heart mRNA profiles of normal and diseased (PPCM) patients