Spermine-induced gene expression change in human macrophages

Polyamines, crucial molecules involved in cell proliferation and growth, play a pivotal role in cancer development and progression. Within the tumor microenvironment, macrophages, key components of the immune system, exhibit a complex relationship with polyamines. Evidence suggests that polyamines can modulate macrophage polarization, influencing their functional phenotypes. Here, we detected the gene expression changes in spermine-stimulated human macrophages isolated from PBMCs. Macrophage isoloated from human PBMCs were devided into two groups: one is Control, the other is spermine-treated group (Spermine). Total RNAs were extracted, and RNA-seq were performed