Comparative genomics of blaNDM-1-producing Escherichia coli ST101 isolates

Extraintestinal pathogenic Escherichia coli (ExPEC) are the leading cause of urinary and systemic infections, where antibiotic resistance complicates successful treatment. Carbapenems are considered a last-resort antibiotic, however the spread of plasmid-encoded carbapenemases such as the New-Delhi Metallo-beta-Lactamase (blaNDM-1) challenges their effectiveness. E. coli ST101 is an emerging, atypical multidrug resistant ExPEC lineage, highly associated with the carriage of blaNDM-1. In this study we analysed the phylogeny and antimicrobial resistance of ST101 isolates from the UK and India.