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Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory [scATAC ex vivo]

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP360548
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We report profiling of single cell chromatin accessbility and gene expression of human NK cells from CMV-seropositive and -negative healthy blood donors ex vivo, as well as chromatin remodeling after in vitro stimulation via NKG2C and/or IL-12+IL-18. Overall design: scATACseq with detection of surface proteins and mitochondrial DNA (ASAP-seq/mtscATAC-seq) of ex vivo isolated human Natural Killer cells
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2024-08-27
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