Molecular perturbations of hepatocytes isolated from nonheart-beating donor rats

Organs from nonheart-beating donors are attractive for use in cell therapy. Understanding the nature of molecular perturbations following reperfusion/reoxygenation would be highly significant for nonheart-beating donor cells. Nonheart-beating donor rats hepatocytes were studied for global gene expression with Affymetrix microarraays.无心跳供体（nonheart-beating donors）来源的器官在细胞治疗中具备良好的应用潜力。阐明再灌注/复氧（reperfusion/reoxygenation）后分子扰动（molecular perturbations）的本质，对无心跳供体细胞的相关研究具有重要价值。本研究针对无心跳供体大鼠肝细胞，采用Affymetrix基因芯片（microarray）开展了全基因组基因表达谱分析。