CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES Descriptor: 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN, MAGNESIUM ION, PROTEIN TYROSINE PHOSPHATASE 1B Authors: Puius, Y.A, Zhao, Y, Sullivan, M, Lawrence, D, Almo, S.C, Zhang, Z.-Y. Deposit date: 1997-01-16 Release date: 1998-03-04 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc.Natl.Acad.Sci.USA, 94, 1997与双(对磷酸苯基)甲烷（BPPM）分子结合的蛋白酪氨酸磷酸酶1B的晶体结构 配体描述：4-磷酸氧基苯基-甲基-[4-磷酸氧基]苯、镁离子、蛋白酪氨酸磷酸酶1B 作者：Puius Y.A.、Zhao Y.、Sullivan M.、Lawrence D.、Almo S.C.、Zhang Z.-Y. 提交日期：1997-01-16 发布日期：1998-03-04 最后修改日期：2024-05-22 实验方法：X射线衍射（1.9 Å） 引用文献：《蛋白酪氨酸磷酸酶1B中第二个芳基磷酸酯结合位点的鉴定：抑制剂设计的范式》，美国国家科学院院刊，第94卷，1997年