PerturBase

PerturBase is the most comprehensive database designed for the analysis and visualization of single-cell perturbation data. It curates 122 datasets from 46 publicly studies, covering 115 single-modal and 7 multi-modal datasets that include 24,254 genetic and 230 chemical perturbations from approximately 5 million cells. PerturBase, comprising the “Dataset” and “Perturbation” modules, provides insights into various analysis results, encompassing quality control, data denoising, differential gene expression analysis, functional analysis of perturbation effects, and characterization of relationships between perturbations.

PerturBase是目前最全面的单细胞扰动数据分析与可视化专用数据库。该库整合了来自46项已公开研究的122套数据集，涵盖115套单模态数据集与7套多模态数据集，包含约500万个细胞中的24254个遗传扰动与230个化学扰动。PerturBase设有"数据集"与"扰动"两大模块，可提供多维度分析结果解读，覆盖质量控制、数据去噪、差异基因表达分析、扰动效应功能分析以及扰动间关联特征刻画等方向。

搜集汇总

背景与挑战

背景概述

PerturBase是一个全面的单细胞扰动数据库，整合了46个研究的122个数据集，涵盖约500万细胞和24,484个扰动。它提供丰富的分析功能和用户友好的可视化工具，支持遗传和化学扰动数据的深入研究。