Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency. Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

Copy-number variation by Comparative Genomic Hybridization (CGH) on thymocytes and Kidney (control) of Tdp2+/+Atm-/- and Tdp2-/-Atm-/- mice. Overall design: 6 independent experiments of Tdp2+/+Atm-/- mice and 3 independent experiments of Tdp2-/-Atm-/ mice.