RNA-seq Analysis of Tgfbr2f/f and Tgfbr2HKO Mouse Liver Transcriptomes
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE214119
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Purpose: To identify the alterations of genes transcriptional profile of livers obtained from Tgfbr2f/f mice and Tgfbr2HKO mice treated with CCl4. Methods: we generated hepatocyte-specific Tgfbr2 knockout (Tgfbr2HKO) mice by AAV8-TBG-Cre injection via the tail vein of Tgfbr2f/f. Tgfbr2f/f mice and Tgfbr2HKO were intraperitoneally injected with 0.25 ml/kg CCl4 (diluted 1:3 (v/v) in olive oil) twice a week for 4 weeks to induce liver fibrosis. Comparative gene expression profiling analysis of RNA-seq data of 12-week old Tgfbr2f/f mice and Tgfbr2HKO mice treated with CCl4.
创建时间：
2022-09-27
