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Remote Activation of the Nucleophilicity of Isatin

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NIAID Data Ecosystem2026-03-08 收录
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The concept of the remote activation of reactivity was first applied in asymmetric organocatalysis. An isatin 3-phenylimine derivative acts as a donor in the thiourea catalyzed asymmetric addition to unsaturated 1,4-ketoesters, affording aza-Michael adducts in high enantiomeric purity and yield.

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2016-02-17
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