Amplitude and desensitization of nAChR responses examined at different temperatures.

†, ††Data for desensitization of all receptor and agonist combinations (with the exception of wild-type α7, activated by ACh) are expressed as the percentage of decay from the peak response in 5 seconds. Due to the rapid rate of desensitization for wild-type α7 activated by ACh, these values are expressed as the time required for the response to decay to 50% of the peak response.Data are means ± SEM. Significant differences to responses recorded at RT are indicated (* = PPP