Additional file 1 of High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients

Additional file 1: Table S1. Differential gene expression analysis. Table S2. Modules of co-expressed genes identified with the Weighted Gene Co-expression Network Analysis (WGCNA). Table S3. Gene module pathway overrepresentation analysis. Table S4. Breast cancer patient survival analysis for genes upregulated in African American patients as compared to White patients. Table S5. Univariate COX regression survival analysis for TNBC Balck/African American patients. Table S6. Multivariate COX regression survival analysis for TNBC Balck/African American patients. Table S7. Analysis of genomic alterations of MKK3. Table S8. Genomic status of MKK3 (MAP2K3 gene) and p38 (MAPK14 gene) in BRCA patients and associated clinical data. Table S9. Correlation between MKK3 overexpression and breast cancer patient survival. Table S10. MKK3 gene set enrichment analysis using the MSigDB cancer Hallmark sets. Table S11. MKK3 gene set enrichment analysis for MYC-regulated gene sets. Table S12. Pathway overrepresentation analysis for MYC-dependent genes enriched in TNBC patients with overexpressed MKK3.附加文件1： 表S1：差异基因表达分析 表S2：采用加权基因共表达网络分析（Weighted Gene Co-expression Network Analysis，WGCNA）鉴定的共表达基因模块 表S3：基因模块通路过表征分析 表S4：相较于白人患者，非裔美国患者中上调基因对应的乳腺癌患者生存分析 表S5：三阴性乳腺癌（Triple-Negative Breast Cancer，TNBC）黑人/非裔美国患者的单因素COX回归生存分析 表S6：三阴性乳腺癌（TNBC）黑人/非裔美国患者的多因素COX回归生存分析 表S7：丝裂原活化蛋白激酶激酶3（Mitogen-activated protein kinase kinase 3, MKK3）基因组变异分析 表S8：乳腺癌（BRCA）患者中MKK3（MAP2K3基因）与p38（MAPK14基因）的基因组状态及相关临床数据 表S9：MKK3过表达与乳腺癌患者生存的相关性分析 表S10：采用分子特征数据库（Molecular Signatures Database，MSigDB）癌症特征标记基因集开展的MKK3基因集富集分析 表S11：针对MYC调控基因集的MKK3基因集富集分析 表S12：针对MKK3过表达的三阴性乳腺癌患者中富集的MYC依赖基因的通路过表征分析