Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the PIF-Pocket
收藏Protein Data Bank Japan2024-11-06 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/5lvo
下载链接
链接失效反馈官方服务：
资源简介：
Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the PIF-Pocket Descriptor: 2-oxidanylidenepropyl ~{N}-(2-chloranyl-6-fluoranyl-phenyl)carbonyl-~{N}'-(4-chlorophenyl)carbamimidothioate, 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. Deposit date: 2016-09-14 Release date: 2016-10-19 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.09 Å) Cite: Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
结合于PIF口袋的变构化合物PSE10与人类3-磷酸肌醇依赖性蛋白激酶1（PDK1）激酶结构域的复合物
描述项：2-氧代亚丙基 N-(2-氯-6-氟苯基)羰基-N'-(4-氯苯基)碳亚胺硫代酯、3-磷酸肌醇依赖性蛋白激酶1、腺苷-5'-三磷酸（ATP）……
作者：Schulze J.O.、Saladino G.、Busschots K.、Neimanis S.、Suess E.、Odadzic D.、Zeuzem S.、Hindie V.、Herbrand A.K.、Lisa M.N.、Alzari P.M.、Gervasio F.L.、Biondi R.M.
提交日期：2016-09-14
发布日期：2016-10-19
最后更新：2024-11-06
实验方法：X射线衍射（分辨率1.09埃）
引用文献：《PDK1蛋白激酶中ATP结合位点与调控性PIF口袋之间的双向变构通讯》，《Cell Chemical Biology》，23卷，2016年
创建时间：
2016-09-14
