Structure of FabS1CE2-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor

Structure of FabS1CE2-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, S1CE2 VARIANT OF FAB-EPR-1 heavy chain, ... Authors: Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S. Deposit date: 2024-01-29 Release date: 2024-07-10 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024FabS1CE2-EPR-1的结构：一款针对促红细胞生成素受体（erythropoietin receptor）的肘关节锁定型高亲和力抗体。描述项：1,2-乙二醇、氯离子、Fab-EPR-1重链S1CE2变体……作者：Singer, A.U、Bruce, H.A、Pavlenco, A、Ploder, L、Luu, G、Blazer, L、Adams, J.J、Sidhu, S.S。沉积日期：2024年1月29日；发布日期：2024年7月10日；最后修改日期：2024年11月13日。实验方法：X射线衍射（2.5 Å）。引用文献：《作为结晶伴侣的、具备优化晶格堆积与肘关节区域构象灵活性提升的抗原结合片段（Fab）》，Protein Sci., 33, 2024