Immune Gene Expression Profile of Tr1 Skewed Tregs
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE143690
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资源简介：
IL-12 and IL-18 synergize to promote TH1 responses and have been implicated as accelerators of autoimmune pathogenesis in type 1 diabetes (T1D). We therefore investigated the influence of these cytokines on phenotype and function of immune cells that are involved in disease progression. To understand how IL-12 and IL-18 may synergize to impair Treg function and phenotype, we conducted transcriptional profiling of Treg expanded under normal conditions or in the presence of IL-12 and IL-18. This analysis revealed increased expression of IFNG, GZMB, GZMA, and IL18RAP and decreased FOXP3 in Tregs expanded with IL-12 and IL-18. Transcriptional profiling of Treg expanded under normal conditions or in the presence of IL-12 and IL-18. 3 samples, 2 conditions each
创建时间：
2020-09-02
