Effects in gene expression of human induced pluripotent stem cells (hiPSCs) co-cultured with mouse embryonic stem cells (mESC)

To investigate the mechanism of naïve-conversion in the neighboring hiPSCs via mRNA transfer from mESCs, the hiPSCs were cultured with or without mESCs. We then performed gene expression profiling analysis using RNA-seq data obtained from two different hiPSCs co-cultured with mESCs. Comparative gene expression profiling analysis of RNA-seq data for hiPSCs co-cultured with mESCs.