Streptomyces sp. Genome sequencing and assembly

The specific environmental conditions of the ocean, especially its high hydrostatic pressure, wide-ranging temperatures, and oligotrophic conditions have affected marine bacteria in various ways, forcing them to adapt to widely different conditions. Importantly, little is known about the genetic mechanisms for environmental adaptation. We hypothesize that one of the environmental factors which play a significant role in bacterial growth and development is temperature. Further, we hypothesize that in adapting to the different environments, bacteria change their metabolomic profiles and antagonistic activity. In our laboratory, it was shown that some marine streptomycetes produce such antibiotics as actinomycin and landomycin in a temperature-dependent manner, but we still do not know the molecular mechanism underlying this phenomenon. Thus, the aim of this project is to describe the temperature dependence of selected arctic bacteria and elucidate the molecular mechanism of the temperature adaptation. We hypothesize that a novel regulatory mechanism underlies this which can be exploited to access other cryptic natural products.