Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56A mutant with pyruvate bound in the active site and R,R-bislysine bound at the allosteric site

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56A mutant with pyruvate bound in the active site and R,R-bislysine bound at the allosteric site Descriptor: (2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid, 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.13 Å) Cite: ALLOSTERIC SITE RESIDUE 'H56' CAPS THE INHIBITOR AT THE TIGHT DIMER INTERFACE FOR TRANSMITTING THE ALLOSTERIC INHIBITION SIGNALS IN Cj.DHDPS To Be Published

来自空肠弯曲菌（C.jejuni）的二氢吡啶二羧酸合酶（Dihydrodipicolinate synthase, DHDPS）H56A突变体，其活性位点（active site）结合丙酮酸，别构位点（allosteric site）结合R,R-双赖氨酸。
描述项：(2R,5R)-2,5-二氨基-2,5-双(4-氨基丁基)己二酸、1,2-乙二醇、4-羟基四氢二吡啶二羧酸合酶等。
作者：萨兰（Saran, S）、桑德斯（Sanders, D.A.R.）
提交日期：2020-11-24
发布日期：2021-12-01
最后修改日期：2023-11-29
实验方法：X射线衍射（2.13 Å）
引用文献：《别构位点残基'H56'在紧密二聚体界面包裹抑制剂，介导空肠弯曲菌DHDPS的别构抑制信号》（待发表）