Adaptive properties of rHK viruses expressing mouse-adapted NS mutations5.
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1Assessed at respective dpi with maximum weight loss for each respective virus.2Fold change values of lung IFN-β levels 1 day pi.3Relative maximum titre obtained 72 hpi (Fig. 6).4Fold change of overall mRNA expression (NP + M1 + NS1; Fig. 7) or overall viral protein expression (M1 + NS1; Fig. 9c–d), respectively.5All fold values are relative to rHK-wt phenotype; where 0 represents below the limit of detection by the respective assay, with the excetion of % mortality, which is expressed as values independent to rHK-wt. (nd, not determined).
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2015-12-02
