Data for: C-Methylated flavanones from the rhizomes of Matteuccia intermedia and their α-glucosidase inhibitory activity

One new flavanonol, demethylmatteucinol (1), and nine new flavanone glucoside derivatives, matteflavosides H-J (2-4) and matteuinterates A-F (5-10), were isolated from the rhizomes of Matteuccia intermedia C.Chr., along with 21 known flavanones (11-31). Notably, all of them contain C-methylation in the A-ring. The structures of the compounds were elucidated by spectroscopic methods and chemical derivatization. The α-glycosidase inhibition assay indicated that compounds 12-17 showed potent inhibitory activity with IC50 values of 12.4-69.7 μM, which suggested their hypoglycemic effect.本研究从中间荚果蕨（Matteuccia intermedia C.Chr.）的根状茎中分离得到1个新的黄烷酮醇类化合物去甲基马特乌奇酚（demethylmatteucinol，编号1），以及9个新的黄烷酮苷类衍生物：荚果黄酮苷H-J（matteflavosides H-J，编号2~4）与荚果中间苷A-F（matteuinterates A-F，编号5~10）；同时获得21个已知黄烷酮类化合物（编号11~31）。值得注意的是，所有分离得到的化合物其A环均带有C-甲基化修饰。所有化合物的结构均通过波谱学方法（spectroscopic methods）与化学衍生法（chemical derivatization）得以阐明。α-糖苷酶抑制实验（α-glycosidase inhibition assay）结果显示，化合物12~17展现出较强的抑制活性，其半抑制浓度（IC50）范围为12.4~69.7 μM，提示此类化合物具备潜在的降血糖活性。