Preparation of α‑Chloroketones via Oxo/Chloro Difunctionalization of Unactivated Alkenes under Mild Conditions

A one-step
synthesis of α-chloroketones via transition metal-free-mediated
oxo/chloro difunctionalization of unactivated alkenes using N-chloro-N-fluorobenzenesulfonamide (CFBSA)
is reported, and both aromatic and aliphatic alkenes can be efficiently
converted into their corresponding α-chloroketones by simply
choosing different conditions. This reaction system has several characteristics
such as a wide substrate scope, excellent functional group tolerance,
mild conditions, low cost, and good yield stability in scale-up reactions,
broadening the methodology for the late-stage modification of drugs
and natural products.