3D cyto- and receptor architectonic map of macaque lateral premotor area F7d

A multimodal analysis of the macaque motor cortex was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey frontal agranular cortex, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 13 different neurotransmitter receptors. The borders of the identified areas were traced onto a reference macaque monkey brain in stereotaxic space. We provide here for the first time a map of lateral premotor area F7d of the macaque monkey brain integrating cyto- and receptor architectonic features in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates, and provides crucial data for modeling approaches with realistic synaptic dynamics.本研究针对猕猴运动皮层开展多模态分析，旨在构建一套整合既往已发表图谱并调和其间分歧的三维图谱（3D atlas）。本研究采用定量且可经统计学检验的方法，分析猕猴额叶无颗粒皮层的细胞构筑特征，并结合体外定量受体放射自显影技术，对13种不同神经递质受体的区域及层状分布模式进行解析。研究人员将所识别脑区的边界标记至立体定位空间中的标准化猕猴脑模板上。本研究首次发布猕猴脑外侧运动前区F7d的图谱，该图谱整合了立体定位空间内的细胞构筑与受体构筑特征。该图谱可为非人灵长类动物的功能实验分析提供宝贵资源，同时为具备真实突触动力学特性的建模研究提供关键数据。