Expression data from renal cortexes of diabetic rats. Rattus norvegicus

Angiotensin II is a key factor driving diabetic nephroparthy via ist AT1R. The role of ist AT2R in diabetic nephropathy is less known, however assumed to be renoprotective We used microarray data to study the effect of transgenic renal AT2R overexpression on the renal expression profile at early stages of diabetes Overall design: In transgenic rats overexpressing the AT2R and wildtype rats diabetes was induced by streptozotocin injection. Kidneys were harvested 28 days therafter for RNA isolation. Nondiabetic transgenic and wildtype rats served as controls.