Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor

Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor Descriptor: (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Scapin, G, Weber, A.E, Biftu, T. Deposit date: 2006-09-28 Release date: 2006-11-28 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.15 Å) Cite: (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes Bioorg.Med.Chem.Lett., 17, 2007与二氮杂环庚烷-2-酮类抑制剂结合的人类二肽基肽酶4，描述项：(3R)-4-[(3R)-3-氨基-4-(2,4,5-三氟苯基)丁酰基]-3-甲基-1,4-二氮杂环庚烷-2-酮、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖等 作者：Scapin, G、Weber, A.E、Biftu, T. 存入日期：2006-09-28 发布日期：2006-11-28 最后修改日期：2024-10-30 实验方法：X射线衍射（分辨率2.15 Å） 引用文献：(3R)-4-[(3R)-3-氨基-4-(2,4,5-三氟苯基)丁酰基]-3-(2,2,2-三氟乙基)-1,4-二氮杂环庚烷-2-酮：一种用于治疗2型糖尿病的选择性二肽基肽酶IV抑制剂，Bioorg.Med.Chem.Lett., 17, 2007