TYROSINE-48 IS THE PROTON DONOR AND HISTIDINE-110 DIRECTS SUBSTRATE STEREOCHEMICAL SELECTIVITY IN THE REDUCTION REACTION OF HUMAN ALDOSE REDUCTASE: ENZYME KINETICS AND THE CRYSTAL STRUCTURE OF THE Y48H MUTANT ENZYME
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TYROSINE-48 IS THE PROTON DONOR AND HISTIDINE-110 DIRECTS SUBSTRATE STEREOCHEMICAL SELECTIVITY IN THE REDUCTION REACTION OF HUMAN ALDOSE REDUCTASE: ENZYME KINETICS AND THE CRYSTAL STRUCTURE OF THE Y48H MUTANT ENZYME Descriptor: ALDOSE REDUCTASE, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Bohren, K.M, Grimshaw, C.E, Lai, C.-J, Gabbay, K.H, Petsko, G.A, Harrison, D.H, Ringe, D. Deposit date: 1994-04-15 Release date: 1994-07-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme. Biochemistry, 33, 1994
《人醛糖还原酶（aldose reductase）还原反应中酪氨酸-48（Tyrosine-48）为质子供体，组氨酸-110（Histidine-110）调控底物立体化学选择性：Y48H突变酶的酶动力学与晶体结构》
描述符：醛糖还原酶（aldose reductase）、柠檬酸（citric acid）、烟酰胺腺嘌呤二核苷酸磷酸（NADP, Nicotinamide-Adenine-Dinucleotide Phosphate）
作者：Bohren, K.M.、Grimshaw, C.E.、Lai, C.-J.、Gabbay, K.H.、Petsko, G.A.、Harrison, D.H.、Ringe, D.
提交日期：1994-04-15
发布日期：1994-07-31
最后修改日期：2024-02-14
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.76埃（Å））
引用文献：《人醛糖还原酶还原反应中酪氨酸-48为质子供体、组氨酸-110调控底物立体化学选择性：Y48H突变酶的酶动力学与晶体结构》，《生物化学（Biochemistry）》，33卷，1994年
创建时间：
1994-04-15
