Data from: Statin use and cognitive function: population-based observational study with long-term follow-up

We aimed to evaluate the association between statin use and cognitive function. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0; best score, 175 points) and the Visual Association Test (VAT; low performance, 0–10; high performance, 11–12 points) in an observational study that included 4,095 community-dwelling participants aged 35–82 years. Data on statin use were obtained from a computerized pharmacy database. Analysis were done for the total cohort and subsamples matched on cardiovascular risk (N = 1232) or propensity score for statin use (N = 3609). We found that a total of 904 participants (10%) used a statin. Statin users were older than non-users: mean age (SD) 61 (10) vs. 52 (11) years (p<0.001). The median duration of statin use was 3.8 (interquartile range, 1.6–4.5) years. Unadjusted, statin users had worse cognitive performance than non-users. The mean RFFT score (SD) in statin users and non-users was 58 (23) and 72 (26) points, respectively (p<0.001). VAT performance was high in 261 (29%) statin users and 1351 (43%) non-users (p<0.001). However, multiple regression analysis did not show a significant association of RFFT score with statin use (B, −0.82; 95%CI, −2.77 to 1.14; p = 0.41) nor with statin solubility, statin dose or duration of statin use. Statin users with high doses or long-term use had similar cognitive performance as non-users. This was found in persons with low as well as high cardiovascular risk, and in younger as well as older subjects. Also, the mean RFFT score per quintile of propensity score for statin use was comparable for statin users and non-users. Similar results were found for the VAT score as outcome measure. In conclusion, statin use was not associated with cognitive function. This was independent of statin dose or duration of statin use.本研究旨在评估他汀类药物使用与认知功能之间的关联。本项观察性研究共纳入4095名年龄介于35至82岁的社区常住居民，采用鲁夫图形流畅性测验（Ruff Figural Fluency Test, RFFT，最低得分0分，最高得分175分）与视觉联想测验（Visual Association Test, VAT，表现不佳者得分0~10分，表现良好者得分11~12分）对受试者的认知功能进行评估。他汀类药物使用情况的数据源自计算机化药房数据库。本研究对全部队列以及按心血管风险匹配（N=1232）或按他汀使用倾向得分（propensity score）匹配（N=3609）的亚组进行了分析。 结果显示，共有904名受试者（占总人群的10%）使用了他汀类药物。他汀使用者的平均年龄高于非使用者：两组平均年龄（标准差SD）分别为61（10）岁与52（11）岁（p<0.001）。他汀类药物使用的中位时长为3.8年（四分位间距1.6~4.5年）。未经校正的分析显示，他汀使用者的认知表现差于非使用者：他汀使用者与非使用者的RFFT平均得分（标准差SD）分别为58（23）分与72（26）分（p<0.001）；VAT表现良好的他汀使用者有261名（占比29%），非使用者有1351名（占比43%）（p<0.001）。 然而，多元回归分析显示，RFFT得分与他汀使用（B=-0.82；95%置信区间CI：-2.77~1.14；p=0.41）、他汀脂溶性、他汀剂量或他汀使用时长均无显著关联。使用高剂量他汀或长期使用他汀的受试者，其认知表现与非使用者相似，这一结果在心血管风险高低不同的人群以及年龄各异的受试者中均成立。此外，按他汀使用倾向得分五分位分组后，他汀使用者与非使用者的RFFT平均得分无显著差异。以VAT得分为结局指标时，也得到了相似的结果。 综上，他汀类药物使用与认知功能无显著关联，且这一结果不受他汀剂量或使用时长的影响。