Candidate genes for Intellectual Disability and Global Development delay with brain expression and conserved interactions between mammals

Representation of conservation of verified interactions for 196 non-DD/ID proteins versus information retrieved using expression data. The analysis conducted with INTERSPIA used ten species: two rodents, and seven primates besides Homo sapiens; applying the same STRING score used previously (0.9). The blue circles represent the 6 hubs detected, the green circles describe the proteins with conserved interactions, and red circles represent genes verified in expression and conservation analysis. Continuous lines symbolize interactions recovered with INTERSPIA, with gray lines among candidate genes and black lines associating interactions between candidate genes and hubs. The dotted lines, on the other hand, reflect interactions between hubs and candidate gene products that showed conserved interactions. To facilitate visualization, the interactions between hubs and candidate genes that showed no evidence of expression were not represented. The PAK2, IQGAP1, DOCK1, DOCK2, DOCK5, PARD6A, PARD6B gene products, interactions of RAC1, were the only conserved interactions that associated directly with the hub and showed evidence of expression in the CNS.