The immunodominant LF epitopes, identified in transgenic mouse strains, show relatively broad binding to common HLA-DR alleles.

The relative binding affinity of peptides to HLA-DR molecules were expressed as a relative activity (ratio of the IC50 of the peptide to the IC50 of the reference peptide which binds strongly to the individual HLA II molecule). Peptides with a high relative binding affinity of <10 are indicated in bold. Means were calculated from at least three independent experiments.