CFL1-induced super enhancer RNA m6A modification promotes local chromatin accessibility and oncogenes transcription in pancreatic cancer [PAR-CLIP]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE211585
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资源简介：
Herein, we describe the landscape of m6A on super enhancer RNAs (seRNAs) in pancreatic ductal adenocarcinoma (PDAC) and demonstrate a regulatory axis involving m6A-seRNAs, H3K4me3 modification, chromatin accessibility and oncogenic transcription. our study has revealed the CFL1-YTHDC2-MLL1 epigenetic regulatory axis plays critical roles of dynamic m6A deposition in seRNAs and local chromatin state, which may be a novel oncogenic mechanism in PDAC and shed light on the crosstalk between epitranscriptome and epigenome. CFL1/METTL3/YTHDC2 PAR-CLIP-seq of PANC-1
创建时间：
2023-09-20
