five

Activation-Enabled Syntheses of Functionalized Pillar[5]arene Derivatives

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NIAID Data Ecosystem2026-03-08 收录
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https://figshare.com/articles/dataset/Activation_Enabled_Syntheses_of_Functionalized_Pillar_5_arene_Derivatives/2153500
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A series of regioselective di- and trifunctionalized pillar[5]­arene derivatives have been synthesized by a deprotection-followed-by-activation strategy, and their constitutions have been established as a result of having access to their solid-state structures. De-O-methylation occurs in a stepwise manner at lower temperatures under kinetic control, affording the desired oligo-substituted pillar[5]­arene derivatives. In addition, the regioisomers of these derivatives can be isolated by installing triflate groups on the free hydroxyl groups.
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2016-02-13
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