Comparison of cerebral blood volume and plasma volume in untreated intracranial tumors

Purpose: Plasma volume and blood volume are imaging-derived parameters that are often used to evaluation intracranial tumors. Physiologically, these parameters are directly related, but their two different methods of measurements, T1-dynamic contrast enhanced (DCE)- and T2-dynamic susceptibility contrast (DSC)-MR utilize different model assumptions and approaches. This poses the question of whether the interchangeable use of T1-DCE-MRI derived fractionated plasma volume (vp) and relative cerebral blood volume (rCBV) assessed using DSC-MRI, particularly in glioblastoma, is reliable, and if this relationship can be generalized to other types of brain tumors. Our goal was to examine the hypothetical correlation between these parameters in three most common intracranial tumor types. Methods: Twenty-four newly diagnosed, treatment naïve brain tumor patients, who had undergone DCE- and DSC-MRI, were classified in three histologically proven groups: glioblastoma (n=7), meningioma (n=9), and in...研究目的：血浆体积与血容量是常用于颅内肿瘤评估的影像学衍生参数。生理层面上，二者存在直接关联，但两种测量方法——T1动态对比增强（T1-dynamic contrast enhanced, DCE）磁共振成像与T2动态磁敏感对比（T2-dynamic susceptibility contrast, DSC）磁共振成像——采用了截然不同的模型假设与分析策略。由此引发了一个关键科学问题：在胶质母细胞瘤中，基于T1-DCE-MRI获取的血浆体积分数（fractionated plasma volume, vp），与通过DSC-MRI评估的相对脑血容量（relative cerebral blood volume, rCBV），二者互换使用是否具备可靠性？该参数间的关联能否推广至其他类型的脑肿瘤？本研究旨在探究三种最常见颅内肿瘤类型中上述参数间的潜在相关性。研究方法：本研究纳入24例初治、未经抗肿瘤治疗的脑肿瘤患者，所有受试者均接受了DCE-MRI与DSC-MRI扫描，经组织病理学证实分为三组：胶质母细胞瘤（n=7）、脑膜瘤（n=9），以及……