Effects of Lewy body disease and Alzheimer’s disease on brain atrophy and cognitive dysfunction

Objectives: We investigated the independent and interaction effects of Alzheimer’s disease (AD) and Lewy body disease (LBD) on cognition and brain atrophy.
Methods: We consecutively recruited 38 controls and 108 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI) from university-based dementia and movement clinics. Diagnoses of ADCI and LBCI were supported by 18F-Florbetaben PET and 18F-FP-CIT-PET, respectively. There were 38 controls, 26 patients with pure ADCI (18 mild cognitive impairment (MCI) and 8 dementia), 28 patients with pure LBCI (13 MCI and 15 dementia), and 54 patients with mixed ADCI and LBCI (17 MCI and 37 dementia). We performed group-wise comparisons for neuropsychological z scores and regional cortical thickness. We also evaluated the effects of ADCI and LBCI using general linear models.
Results: Compared to the controls, pure patients with ADCI group and pure LBCI group had focused cortical thinning in the bilateral en...