Effects of Lewy body disease and Alzheimer’s disease on brain atrophy and cognitive dysfunction

Objectives: We investigated the independent and interaction effects of Alzheimer’s disease (AD) and Lewy body disease (LBD) on cognition and brain atrophy. Methods: We consecutively recruited 38 controls and 108 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI) from university-based dementia and movement clinics. Diagnoses of ADCI and LBCI were supported by 18F-Florbetaben PET and 18F-FP-CIT-PET, respectively. There were 38 controls, 26 patients with pure ADCI (18 mild cognitive impairment (MCI) and 8 dementia), 28 patients with pure LBCI (13 MCI and 15 dementia), and 54 patients with mixed ADCI and LBCI (17 MCI and 37 dementia). We performed group-wise comparisons for neuropsychological z scores and regional cortical thickness. We also evaluated the effects of ADCI and LBCI using general linear models. Results: Compared to the controls, pure patients with ADCI group and pure LBCI group had focused cortical thinning in the bilateral en...研究目标：本研究探讨了阿尔茨海默病（Alzheimer’s disease, AD）与路易体病（Lewy body disease, LBD）各自及交互作用对认知功能与脑萎缩的影响。 研究方法：本研究从大学附属痴呆症与运动障碍门诊连续招募38名健康对照者，以及108例伴有阿尔茨海默病相关认知障碍（AD-related cognitive impairment, ADCI）和/或路易体病相关认知障碍（LBD-related cognitive impairment, LBCI）的患者。ADCI与LBCI的诊断分别通过18F-氟贝他班PET（18F-Florbetaben PET）与18F-FP-CIT-PET予以确认。本研究队列包含38名健康对照者、26例单纯ADCI患者（18例轻度认知障碍（MCI）与8例痴呆患者）、28例单纯LBCI患者（13例轻度认知障碍与15例痴呆患者），以及54例混合性ADCI与LBCI患者（17例轻度认知障碍与37例痴呆患者）。本研究对神经心理学z评分及区域皮层厚度进行组间比较，并通过一般线性模型评估ADCI与LBCI的影响效应。 研究结果：与健康对照组相比，单纯ADCI组与单纯LBCI组患者均在双侧……出现局限性皮层变薄。