Raw data for NCOMMS-24-14659B

RNA-Seq data set

BA and cholesterol metabolomics and liver lipidomic nalyses in the liver - hPXR/hCAR/hCYP3A mice on HFD diet treated with MI-883 for 4 weeks

MARCoNI datase

plasma metabolomics

microscopic and macrioscopic figures

Funding
Technology Agency of the Czech Republic TN02000109
Ministry of Defence of the Czech Republic (project no: DZRO-FVZ22-ZHN II
Czech Science Foundation No.22-05167S
OP JAK project NETPHARM, project ID CZ.02.01.01/00/22_008/0004607, is co-funded by the European Union.
M.H. acknowledges the support of ERC Adv grant No. 101095860 sponsored by the European Research Council.
T.K. is funded by the fortune initiative and from TüCAD2 and CMIF. TüCAD2 and CMIF are funded by the Federal Ministry of Education and Research (BMBF) and the Baden-Württemberg Ministry of Science as part of the Excellence Strategy of the German Federal and State Governments.
The authors used services of the Czech Centre for Phenogenomics at the Institute of Molecular Genetics supported by the Czech Academy of Sciences RVO 68378050 and by the project LM2023036 Czech Centre for Phenogenomics provided by Ministry of Education, Youth and Sports of the Czech Republic. CZ.02.01.01/00/23_015/0008189 Upgrade of the large research infrastructure CCP III co-funded by EU and MEYS CZ.02.1.01/0.0/0.0/18_046/0015861 CCP Infrastructure Upgrade II by MEYS and ESIF
A.R., T.K., and P.P. acknowledge the European Union’s Horizon 2020 research and innovation program under grant agreement No 825762, EDCMET project Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways (EDCMET).