Risk of hepatocellular carcinoma (HCC) by quartile (Q) of plasma sPD-1 levels: case-cohort and case-control studies^a.

aORs and 95% CIs were mutually adjusted for age (continuous variable), cigarette smoking (yes or no), and alcohol consumption (yes or no), except for models 2 & 3. bModel 2: ORs and 95% CIs were mutually adjusted for age (continuous variable), cigarette smoking (yes or no), alcohol consumption (yes or no), first-degree family history of HCC (yes or no), BMI (≥25 or <25 kg/m2), and HBV viral load (≥4.39 or <4.39 log copies/mL). cModel 3: ORs and 95% CIs were mutually adjusted for age (continuous variable), cigarette smoking (yes or no), alcohol consumption (yes or no), first-degree family history of HCC (yes or no), BMI (≥25 or <25 kg/m2), HBV viral load (≥4.39 or <4.39 log copies/mL), and ALT>ULN (yes or no). dORs and 95% CIs for HCC according to sPD-1 quartile levels were derived from comparisons between the entire or subgroups (as indicated below) of hospital-based cases vs. the 1155 noncases from the case-cohort study. eDefined as solitary tumor ≤5 cm or <4 lesions and none>3 cm. CI, confidence interval; OR, odds ratio; ULN, upper limit of normal. Risk of hepatocellular carcinoma (HCC) by quartile (Q) of plasma sPD-1 levels: case-cohort and case-control studiesa.